Transition-Metal-Catalyzed or -Free Direct Oxidative Reactions

Transition metal-catalyzed reactions are among the most powerful tools in organic and medicinal synthesis as they are effective promoters and catalysts for oxidative cross-coupling reactions. We have invested extensive efforts in the development of pdenyadium-, ruthenium-, rhodium-, iridium-, copper-, gold-, silver-, and nickel-catalyzed reactions. While the scope of the oxidative coupling is highly diversified, our lab particularly aims to develop the oxidative coupling reactions concerning C–C, C-N, C-S, and C-O bond formation.

We also aim to develop sustainable oxidative coupling reactions, using simple and inexpensive catalysts and low molecular weight oxidants under transition metal-free conditions.

Selected works on Transition-Metal-Catalyzed or -Free Direct Oxidative Reactions

Direct Oxidative Arylation of C(sp3)-H Bonds Adjacent to Oxygen of Ethers and Alcohols
(Adv. Synth. Catal. 2014, 356, 3171 – 3179)

Copper(I) Bromide-Dimethyl Sulfide-Catalyzed Direct Sulfanylation of 4-Hydroxycoumarins and 4-Hydroxyquinolinones with Arylsulfonylhydrazides and Selective Fluorescence Switch-On Sensing of Cadmium(II) Ion in Water
(Adv. Synth. Catal. 2016, 358, 3050)

Transition Metal-Free Iodosobenzene-Promoted Direct Oxidative 3-Arylation of Quinoxalin-2(H)-ones with Arylhydrazines
(Adv. Synt. Catal. 2017, 359, 1515-1521)