Organic Synthesis Utilizing Diazo Compounds

Diazo compounds, ranging from simple diazoalkanes to highly substituted diazocarbonyl compounds, play an important role in modern organic synthesis. With the development of new catalysts of Ru, Rh, In, Ag, Cu, Co etc. for their decomposition, diazo compounds can be uniquely used in chemoselective, regioselective, and stereoselective controlled reactions to generate carbon–carbon and carbon–heteroatom bonds for the synthesis of pharmaceutically important small organic molecules.

Selected works on organic synthesis utilizing diazo compounds

Synthesis of diverse indenes from  1-diazonaphthalen-2(1H)-ones via thermal cascade reactions
(Org. Lett. 2013, 15, 4288)

 

One‐Pot Synthesis of Multi‐Substituted 4‐Pyrones by a Gold‐Catalyzed Cascade of Wolff Rearrangement/[4+2] Cycloaddition/ Elimination Reactions
(Adv. Synth. Catal. 2014, 356, 2566)

Ruthenium(II)-Catalyzed Protocol for Preparation of Diverse α,β- and β,β-Dihaloenones from Diazodicarbonyls
(Adv. Synth. Catal. 2014, 356, 3422)

Synthesis of α,β-dihaloenones

Synthesis of β,β-dihaloenones

Construction of Multifunctionalized Azopyrazoles by Silver‐Catalyzed Cascade Reaction of Diazo Compounds
(Adv. Synth. Catal. 2015, 357, 2657)

Synthesis of multifunctionalized azopyrazoles