Construction of Aromatics and Heteroaromatics via Benzannulation and N-Annulation

Recently, benzannulation and N-annulation reactions are among the most important reactions for the formation of highly functionalized aromatics and heteroaromatics.  Over the past decade, several synthetic methods for benzannulation have been reported namely as Diels-Alder reaction, Bergman cyclization, Danheiser annulation, ring closing metathesis, Dötz [3+2+1] reaction, Wulff [5+1] orthobenzannulation, and rhodium(II)-catalyzed benzannulation. Our study also aims to demonstrate novel and improved ways to synthesize aromatics and heteroaromatics.

Selected works on benzannulation/N-annulation

Transition-Metal-Free Benzannulation for Diverse and Polyfunctionalized Biaryl Formation
(Org. Lett.201517, 2050–2053)

Organocatalyzed benzannulation for the construction of diverse anthraquinones and tetracenediones
(Chem. Commun., 2015, 51, 8592-8595)

Construction of highly functionalized carbazoles via condensation of an enolate to a nitro group
(Chem. Sci., 2015,6, 7028-7033)

Organocatalyzed oxidative N-annulation for diverse and polyfunctionalized pyridines
(Chem. Commun., 2015,51, 9467-9470)

Eco-friendly synthesis of diverse and valuable 2-pyridones by catalyst- and solvent-free thermal multicomponent domino reaction
(Green Chem., 2015, 17, 4579-4586)

Eco-friendly construction of highly functionalized chromenopyridinones by an organocatalyzed solid-state melt reaction and their optical properties
(Green Chem., 2016, 18, 1488-1494)

Regioselective construction of diverse and multifunctionalized 2-hydroxybenzophenones for sun protection indium(III)-catalyzed benzannulation
(Chem. Commun., 2016, 52, 7661-7664)